| | Scilex Holding Co | Drug Manufacturers - General | Healthcare | 5.44 | -12.19 | -28.60 | -45.03 | -68.17 | -81.35 | -98.23 | -97.33 |
| | Scilex Holding Co Wt | Drug Manufacturers - General | Healthcare | 0.00 | 29.70 | 18.99 | -35.15 | -48.14 | -67.58 | -96.29 | -16.97 |
| | MIRA Pharmaceuticals Inc | Drug Manufacturers - General | Healthcare | -0.17 | -6.27 | -13.03 | -33.05 | -21.89 | -15.56 | -88.63 | -88.63 |
| | Novo Nordisk A/S ADR | Drug Manufacturers - General | Healthcare | -5.96 | -8.78 | -21.58 | -28.23 | -47.32 | -50.26 | -20.84 | 5.40 |
| | Organon & Co | Drug Manufacturers - General | Healthcare | -9.57 | -20.90 | -27.34 | -26.56 | -34.11 | -32.93 | -45.47 | -61.55 |
| | Biogen Inc | Drug Manufacturers - General | Healthcare | -5.90 | -13.26 | -24.77 | -23.81 | -39.88 | -43.75 | -59.92 | -46.17 |
| | Merck & Co Inc | Drug Manufacturers - General | Healthcare | -5.32 | -10.23 | -17.86 | -21.19 | -27.93 | -37.00 | -27.15 | -2.45 |
| | Amarin Corp Plc ADR | Drug Manufacturers - General | Healthcare | -1.48 | 6.84 | -2.94 | -18.18 | -22.53 | -56.59 | -67.28 | -86.52 |
| | Pfizer Inc | Drug Manufacturers - General | Healthcare | -4.00 | -11.12 | -18.96 | -17.86 | -24.04 | -12.83 | -42.19 | -54.16 |
| | Grifols S.A. ADR | Drug Manufacturers - General | Healthcare | -5.92 | -8.30 | -16.41 | -10.56 | -24.45 | -6.46 | -11.29 | -40.51 |
| | Eli Lilly & Co | Drug Manufacturers - General | Healthcare | -4.35 | -8.64 | -13.12 | -9.74 | -20.59 | -4.80 | 99.32 | 139.77 |
| | Bristol Myers Squibb Co | Drug Manufacturers - General | Healthcare | -6.10 | -11.78 | -19.18 | -8.64 | -1.58 | 5.27 | -21.44 | -25.58 |
| | AstraZeneca Plc ADR | Drug Manufacturers - General | Healthcare | -2.83 | -12.24 | -14.63 | -1.81 | -14.41 | -2.81 | -6.16 | -2.17 |
| | AbbVie Inc | Drug Manufacturers - General | Healthcare | -3.14 | -13.61 | -19.60 | 0.38 | -8.80 | 6.81 | 16.47 | 14.82 |
| | Sanofi ADR | Drug Manufacturers - General | Healthcare | -3.03 | -9.08 | -16.33 | 1.91 | -9.33 | 8.57 | -1.25 | -1.78 |
| | GSK Plc ADR | Drug Manufacturers - General | Healthcare | -2.55 | -13.87 | -16.67 | 2.65 | -12.40 | -14.08 | -3.97 | -18.68 |
| | Johnson & Johnson | Drug Manufacturers - General | Healthcare | -1.51 | -6.96 | -11.34 | 5.50 | -5.87 | 2.17 | -3.74 | -9.66 |
| | Novartis AG ADR | Drug Manufacturers - General | Healthcare | -0.43 | -7.89 | -8.38 | 6.77 | -7.86 | 12.09 | 13.25 | 17.32 |
| | Amgen Inc | Drug Manufacturers - General | Healthcare | -3.33 | -9.18 | -14.04 | 8.18 | -10.92 | 8.83 | 19.47 | 23.28 |
| | Gilead Sciences Inc | Drug Manufacturers - General | Healthcare | -3.66 | -9.78 | -12.88 | 13.61 | 21.61 | 54.44 | 32.38 | 84.16 |
| | Medicus Pharma Ltd | Drug Manufacturers - General | Healthcare | -11.14 | -10.67 | -1.47 | 20.07 | 26.42 | 26.42 | 26.42 | 26.42 |
