| | Organon & Co | Drug Manufacturers - General | Healthcare | -9.69 | -10.06 | -8.68 | -14.15 | -26.05 | -22.19 | -35.66 | -55.51 |
| | Scilex Holding Co | Drug Manufacturers - General | Healthcare | -9.31 | 6.08 | -14.17 | -49.39 | -73.66 | -83.13 | -96.74 | -97.24 |
| | AstraZeneca Plc ADR | Drug Manufacturers - General | Healthcare | -7.39 | -7.22 | -11.38 | 3.89 | -10.37 | 3.74 | 1.60 | 9.37 |
| | MIRA Pharmaceuticals Inc | Drug Manufacturers - General | Healthcare | -7.29 | -21.28 | -10.28 | -33.78 | -27.44 | -18.20 | -88.75 | -88.75 |
| | AbbVie Inc | Drug Manufacturers - General | Healthcare | -7.28 | -8.93 | -10.01 | 4.79 | -2.09 | 15.41 | 26.18 | 29.27 |
| | Novo Nordisk A/S ADR | Drug Manufacturers - General | Healthcare | -6.78 | -8.70 | -27.69 | -25.59 | -45.04 | -48.77 | -18.94 | 14.46 |
| | Grifols S.A. ADR | Drug Manufacturers - General | Healthcare | -6.47 | -8.53 | -19.59 | -15.39 | -25.45 | -3.06 | -7.25 | -45.36 |
| | Eli Lilly & Co | Drug Manufacturers - General | Healthcare | -6.45 | -10.25 | -18.97 | -3.37 | -16.53 | -3.29 | 111.23 | 160.31 |
| | GSK Plc ADR | Drug Manufacturers - General | Healthcare | -6.36 | -5.70 | -4.94 | 8.75 | -3.80 | -6.98 | 8.17 | -6.07 |
| | Biogen Inc | Drug Manufacturers - General | Healthcare | -5.91 | -11.12 | -13.79 | -19.76 | -33.77 | -40.10 | -55.32 | -41.89 |
| | Novartis AG ADR | Drug Manufacturers - General | Healthcare | -5.71 | -5.97 | -2.80 | 10.85 | -4.96 | 11.77 | 18.69 | 28.93 |
| | Merck & Co Inc | Drug Manufacturers - General | Healthcare | -5.70 | -8.70 | -11.22 | -17.60 | -24.54 | -34.29 | -20.81 | 6.33 |
| | Pfizer Inc | Drug Manufacturers - General | Healthcare | -5.43 | -8.89 | -10.80 | -13.17 | -17.03 | -8.41 | -37.25 | -48.37 |
| | Amgen Inc | Drug Manufacturers - General | Healthcare | -4.99 | -4.09 | -5.70 | 14.76 | -6.42 | 13.16 | 26.68 | 32.13 |
| | Sanofi ADR | Drug Manufacturers - General | Healthcare | -4.83 | -6.88 | -9.91 | 5.67 | -6.29 | 12.05 | 4.85 | 12.42 |
| | Amarin Corp Plc ADR | Drug Manufacturers - General | Healthcare | -4.73 | -8.54 | -21.07 | -23.36 | -33.54 | -62.02 | -71.85 | -88.91 |
| | Gilead Sciences Inc | Drug Manufacturers - General | Healthcare | -4.57 | -4.06 | -5.87 | 18.39 | 28.75 | 59.99 | 40.84 | 98.70 |
| | Johnson & Johnson | Drug Manufacturers - General | Healthcare | -4.12 | -6.40 | -7.36 | 7.52 | -2.86 | 3.71 | 2.86 | -5.12 |
| | Medicus Pharma Ltd | Drug Manufacturers - General | Healthcare | -3.47 | 15.67 | 24.83 | 25.69 | 36.60 | 36.60 | 36.60 | 36.60 |
| | Bristol Myers Squibb Co | Drug Manufacturers - General | Healthcare | -3.32 | -6.87 | -5.96 | -1.38 | 4.74 | 12.88 | -11.47 | -15.45 |
| | Scilex Holding Co Wt | Drug Manufacturers - General | Healthcare | 0.00 | -0.20 | 0.05 | -52.38 | -54.25 | -74.99 | -91.30 | -35.98 |
